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Counter target instant or sorcery spell.
Transmute (, Discard this card: Search your library for a card with the same converted mana cost as this card, reveal it, and put it into your hand. Then shuffle your library. Transmute only as a sorcery.)
Muddle the Mixture may only counter instants and sorceries, but its Transmute ability makes it useful in Commander. If it isn't applicable, you can always find another two-mana answer.